As cyber threats evolve, businesses need next-gen antivirus solutions that go beyond traditional methods to protect against sophisticated attacks. The top 10 enterprise next-gen antivirus solutions of 2025 offer cutting-edge features, including advanced endpoint protection and cloud-native antivirus solutions, to safeguard your network. Whether you’re looking for the best antivirus for businesses in 2025 or seeking enterprise-level antivirus software to secure your organization’s infrastructure, this guide will help you choose the best fit. With top EDR solutions in 2025, these solutions provide comprehensive security against ransomware, malware, and other emerging threats. Let’s dive into the top next-gen antivirus for enterprises and explore how they enhance your overall cybersecurity strategy.
Also check Top 10 Intrusion Detection Systems (IDS) for Enterprise Security
1. CrowdStrike Falcon
Unique Features
✅ Cloud-Native Architecture: Designed to be deployed in the cloud, which minimizes hardware dependency.
✅ AI and ML-Powered Protection: Uses machine learning to detect and prevent even the most sophisticated threats in real time.
✅ Endpoint Detection and Response (EDR): Provides comprehensive monitoring, threat detection, and automated incident response.
✅ Integrated Threat Intelligence: Offers real-time intelligence to prevent attacks and helps organizations respond to emerging threats.
✅ Behavioral Analytics: Detects malicious behavior patterns, even from previously unknown threats.
Limitations
❌ Pricing: CrowdStrike Falcon can be expensive, especially for small businesses looking for premium features.
❌ Setup Complexity: The platform may require specialized knowledge for proper configuration.
❌ High Resource Consumption: Some users have reported the software can consume considerable system resources, affecting device performance.
Pricing
- Starting at: $99.99 per endpoint, per year for the Falcon Pro plan.
- Official Website: CrowdStrike Falcon
2. Sophos Intercept X
Unique Features
✅ Deep Learning AI: Combines AI with deep learning technology to detect malware and unknown threats before they strike.
✅ Anti-Ransomware: Includes proactive ransomware detection and blocking capabilities.
✅ Exploit Prevention: Prevents vulnerabilities in software from being exploited by attackers.
✅ Managed Threat Response: Sophos offers a 24/7 monitoring and managed service that assists with threat remediation.
✅ Endpoint Detection and Response (EDR): Provides real-time threat detection and automated incident response.
Limitations
❌ Price: Sophos Intercept X can be on the higher end for pricing, especially for small businesses.
❌ User Interface Complexity: Some users report that the interface is not as intuitive as other solutions.
❌ Resource Intensity: The solution can consume considerable system resources, especially when running advanced features.
Pricing
- Starting at: $40 to $60 per endpoint, per year, depending on the features and services.
- Official Website: Sophos Intercept X
3. Microsoft Defender for Endpoint
Unique Features
✅ Seamless Integration with Microsoft Ecosystem: Fully integrates with Microsoft 365 and Windows, offering a unified security platform for businesses already using Microsoft products.
✅ Cloud Intelligence: Utilizes Microsoft’s vast cloud infrastructure to analyze and detect threats at scale.
✅ Automated Investigation and Remediation: Reduces manual intervention by automating investigations and responding to threats swiftly.
✅ Vulnerability Management: Helps businesses identify and fix vulnerabilities within their network to prevent potential breaches.
✅ Endpoint Detection and Response (EDR): Continuous monitoring and immediate threat detection across endpoints.
Limitations
❌ Limited Support for Non-Windows Devices: Although powerful, the platform’s capabilities are mostly focused on Windows devices, offering less robust support for macOS and Linux.
❌ Complex Configuration: For large enterprises, setting up and configuring Defender for Endpoint properly can be complicated.
❌ Less Granular Control: Some advanced users report that Microsoft Defender does not provide the level of granular control other NGAV solutions offer.
Pricing
- Starting at: $10 to $57 per user per month, depending on the plan.
- Official Website: Microsoft Defender for Endpoint
4. SentinelOne Singularity
Unique Features
✅ Autonomous Endpoint Protection: Offers autonomous threat detection and response capabilities with AI-driven analysis.
✅ Integrated EDR: Combines EDR capabilities to monitor and respond to attacks in real-time.
✅ Automated Threat Response: Leverages AI and ML to automatically respond to and mitigate threats, reducing manual intervention.
✅ Real-Time Detection: Identifies and stops threats in real time using continuous monitoring and behavior-based detection.
Limitations
❌ Pricing: SentinelOne is considered one of the more expensive solutions, especially for smaller organizations.
❌ Complex Deployment: Large-scale deployments may require technical expertise for proper configuration and management.
❌ Cloud-Dependent: Being a cloud-native solution, it might face issues in environments where cloud services are restricted.
Pricing
- Starting at: Pricing available upon request.
- Official Website: SentinelOne Singularity
5. Trellix Endpoint Security Suite
Unique Features
✅ Comprehensive Endpoint Protection: Includes antivirus, EDR, and data loss prevention (DLP) in a single solution.
✅ Advanced Threat Prevention: Utilizes machine learning to detect and block advanced persistent threats (APTs).
✅ Cloud-Based Management: Trellix provides centralized, cloud-based management for efficient enterprise-wide security deployment.
✅ Real-Time Threat Intelligence: Integrated threat intelligence tools help businesses stay one step ahead of emerging threats.
Limitations
❌ Pricing: Pricing information is available upon request, but it can be costly for smaller organizations.
❌ Steep Learning Curve: Some users have noted that the platform may require a significant amount of time to fully learn and master.
Pricing
- Starting at: Pricing available upon request.
- Official Website: Trellix Endpoint Security Suite
6. ESET PROTECT
Unique Features
✅ Comprehensive Security Suite: Provides antivirus, anti-malware, firewall, and intrusion detection in a single package.
✅ Lightweight and Efficient: Known for its minimal system impact, ESET PROTECT is light on resources while offering robust protection.
✅ Cloud-Based Management: Offers cloud-based management for easy control and monitoring of security across endpoints.
✅ Multi-Layered Protection: Utilizes multiple security layers to protect against advanced malware and ransomware.
Limitations
❌ Limited Advanced Features: Lacks some of the more advanced features offered by competitors like deep learning AI or automated remediation.
❌ Interface May Be Overwhelming: The user interface can be overwhelming for smaller businesses or users with limited experience in security tools.
Pricing
- Starting at: $29.99 per endpoint, per year.
- Official Website: ESET PROTECT
7. Bitdefender GravityZone Business Security
Unique Features
✅ Cloud-Based Protection: Offers centralized, cloud-based security management for enterprises.
✅ AI-Powered Malware Detection: Uses AI and machine learning to detect and block emerging threats.
✅ Firewall & Application Control: Provides robust firewall protection and allows fine-grained control over applications.
✅ Advanced Anti-Ransomware: Includes specialized protection for ransomware threats, which have become increasingly common.
Limitations
❌ Pricing: Some users have found the pricing to be on the higher side for small to medium-sized enterprises.
❌ Complex Setup: Initial setup and deployment can be complex, especially for businesses without dedicated IT staff.
Pricing
- Starting at: $29.99 per device, per year.
- Official Website: Bitdefender GravityZone Business Security
8. Kaspersky Endpoint Security for Business
Unique Features
✅ Advanced Malware Detection: Uses machine learning to detect and block malware and unknown threats in real time.
✅ Automated Threat Response: Offers automated remediation to reduce the impact of detected threats.
✅ Comprehensive Protection: Combines antivirus, anti-malware, firewall, and other advanced protections in a single solution.
✅ Cloud Integration: Provides centralized cloud management for easy control and deployment across the organization.
Limitations
❌ Pricing: Kaspersky is on the pricier side for smaller organizations.
❌ Geopolitical Concerns: Some enterprises, particularly those in government sectors, may hesitate to use Kaspersky due to concerns over its Russian origin.
Pricing
- Starting at: Pricing available upon request.
- Official Website: Kaspersky Endpoint Security for Business
9. Trend Micro Apex One
Unique Features
✅ AI-Powered Protection: Uses AI and machine learning to detect and block new and unknown threats in real time.
✅ Ransomware Protection: Includes specialized protection to prevent ransomware attacks from encrypting critical files.
✅ Endpoint Detection and Response (EDR): Provides continuous monitoring and rapid response to threats.
✅ Behavioral Analysis: Monitors suspicious behavior and automatically takes action against potential threats.
Limitations
❌ Pricing: Higher cost for businesses looking for full-featured solutions.
❌ Resource Intensive: Some users report that it can consume significant system resources.
Pricing
- Starting at: Pricing available upon request.
- Official Website: Trend Micro Apex One
10. Panda Security Adaptive Defense
Unique Features
✅ Behavior-Based Protection: Focuses on prevention rather than detection, identifying threats based on their behavior.
✅ Cloud-Based Management: Offers centralized cloud-based management for remote deployment.
✅ Comprehensive Threat Intelligence: Leverages data from the cloud to anticipate and prevent advanced attacks.
✅ Real-Time Response: Provides real-time protection with automated responses to threats.
Limitations
❌ Pricing: Higher price point compared to more basic antivirus tools.
❌ Limited Customization: Offers fewer customization options than some competitors.
Pricing
- Starting at: Pricing available upon request.
- Official Website: Panda Security Adaptive Defense
FAQs
1. What is the best antivirus for businesses in 2025?
The Top 10 Enterprise Next-Gen Antivirus solutions for 2025 provide robust, AI-powered protection against evolving cyber threats. These solutions, such as CrowdStrike Falcon, Sophos Intercept X, and SentinelOne Singularity, offer advanced endpoint protection and real-time threat detection, ideal for businesses looking to stay ahead of cybercriminals.
2. Why should enterprises use Next-Gen antivirus for cybersecurity?
Next-Gen antivirus for enterprises leverages AI-powered antivirus solutions that go beyond traditional signature-based protection. These solutions offer advanced endpoint protection, including ransomware protection for enterprises, cloud-based management, and automated threat response, making them more effective against sophisticated attacks.
3. What are some top NGAV solutions for businesses in 2025?
Some of the top NGAV solutions for businesses in 2025 include CrowdStrike Falcon, Sophos Intercept X, and Microsoft Defender for Endpoint. These enterprise-level antivirus software options provide integrated EDR capabilities, cloud-native antivirus solutions, and comprehensive protection from ransomware, malware, and other advanced threats.
4. What are EDR solutions, and how do they help businesses?
Top EDR solutions in 2025, like Microsoft Defender for Endpoint and Bitdefender GravityZone, provide real-time monitoring, threat detection, and automated incident response. These solutions are essential for enterprises, as they provide comprehensive protection against cyber threats, minimize damage, and reduce response times to security incidents.
5. How do AI-powered antivirus solutions detect emerging threats?
AI-powered antivirus solutions use machine learning algorithms and behavioral analysis to detect new, previously unknown threats. Unlike traditional solutions that rely on signatures, these next-gen antivirus tools can identify suspicious patterns and behaviors, preventing attacks like ransomware and advanced malware.
6. Can cloud-native antivirus solutions provide better protection for enterprises?
Yes, cloud-native antivirus solutions offer several advantages for enterprises, including seamless scalability, faster updates, and centralized management. These solutions, such as CrowdStrike Falcon and Trellix Endpoint Security, allow for real-time protection against cyber threats without the need for extensive hardware or local resources.
7. How do I choose the right enterprise-level antivirus software for my business?
When choosing enterprise-level antivirus software, consider factors like scalability, integration with existing infrastructure, automated threat response capabilities, and the level of advanced endpoint protection provided. Look for AI-powered antivirus solutions that offer EDR features, cloud-native protection, and advanced ransomware protection.
Summary
Choosing the Top 10 Enterprise Next-Gen Antivirus solutions for your business is critical in today’s evolving cybersecurity landscape. AI-powered antivirus solutions, advanced endpoint protection, and cloud-native antivirus solutions are key to defending against sophisticated threats such as ransomware and zero-day attacks. Solutions like CrowdStrike Falcon, Sophos Intercept X, and SentinelOne Singularity offer integrated EDR capabilities, proactive ransomware protection for enterprises, and real-time threat detection.
These next-gen antivirus for enterprises combine cutting-edge technologies such as machine learning and behavioral analytics to offer comprehensive protection, automating threat response and significantly reducing response times. With top EDR solutions and enterprise-level antivirus software, these tools empower businesses to safeguard their data and assets more effectively than ever before.
If you are looking for next-gen antivirus solutions for 2025, be sure to choose one that offers scalable protection, seamless integration with your IT infrastructure, and robust support for multi-device environments. For more information on enterprise-level security solutions, check out the latest endpoint protection reviews and cybersecurity best practices on trusted platforms like Gartner and TechRepublic.